ST101 is a peptide inhibitor of C/EBPβ, which is a transcription factor overexpressed in many cancers that regulate cellular differentiation and promote tumor survival and proliferation. ST101 significantly decreases the expression of C/EBPβ target genes/proteins involved in cell survival, proliferation and differentiation including BCL-2, MCL-1, BIRC5/survivin, cyclins and ID family of proteins. ST101 has been demonstrated to induce selective cancer cell cytotoxicity across a variety of tumor types, including but not limited to breast cancer, melanoma, prostate cancer, GBM, lung cancer, and AML.
C/EBPβ is expressed and active in cancer cells but not active in normal cells (post-differentiation), providing a therapeutic opportunity. By inhibiting the actions of C/EBPβ, ST101 is a tumor-specific treatment that induces tumor cell death by apoptosis and has the potential to sensitize cancer cells to radiation and/or chemotherapy. The impact of ST101 on radiation and chemotherapy sensitivity provides a rationale for combining ST101 with traditional cancer treatment regimens as it advances in clinical development.
Initial clinical studies will focus on HRPOS breast cancer, I/O-refractive melanoma, castration-resistant prostate cancer (CRPC), and GBM. Additional oncology indications for which there is already in vivo and/or in vitro data, including AML, will also be pursued.View Clinical Trial