Current drugs on the market have limitations that prevent them from drugging intracellular protein-protein interactions (PPIs). Small molecules can reach the PPI but are too small to effectively disrupt or prevent their formation. Large molecules can effectively disruptor prevent the formation of PPIs but are too large to pass through the cell membrane and enter cells. At Sapience, we are developing peptide-based therapeutics that combine the best properties of small and large molecules while eliminating their shortcomings.
We believe peptides provide the best opportunity to address these desired drug-targets. Peptides are small enough to travel around the body, through the cell membrane and into the cytoplasm or nucleus, and are large enough to prevent and disrupt specific PPIs.