Targeting Dysregulated Protein-Protein Interactions

The interaction of proteins is important to maintain normal cellular homeostasis in the body. Examples of protein-protein interactions (PPIs) include receptor/ligand interactions, intracellular signaling cascades, and transcription complexes. When PPIs become aberrant or dysregulated in cells, they may lead to cancer, however, due to their large size, complex interactions and resistance to traditional cancer treatment they are considered “undruggable.”